Viral innate sensor

Recently, the lab of Prof. Siddharth Balachandran shows in CELL that the protein ZBP1 detects a certain form of viral RNA (Z-form) in the nucleus triggering the kinase MLKL1, consequently leading to nuclear enveloppe disruption, DNA leaking and necroptosis.
They used anti-ZBP1, mAb (Zippy-1) (Prod. No. AG-20B-0010) from AdipoGen Life Sciences in their studies, confirming the specificity of Zippy-1 in mouse (ZBP1 KO mice) and human cells. Reference.