Progranulin – Marker of Neuroinflammation

Progranulin (PGRN) is a cysteine-rich protein, that shows multifunctional biological activities, including major roles in cancer, inflammation, metabolic disease and neurodegeneration, especially as a valuable biomarker for Frontotemporal Lobar Degeneration (FTLD). In the brain, PGRN is primarily expressed in mature neurons and microglia. The absence of progranulin in microglia causes increased production and release of multiple cytokines. It is anticipated that PGRN affects microglial proliferation, recruitment, differentiation, activation and phagocytosis, suggesting that PGRN plays a central role in the regulation of neuroinflammatory responses. Extracellular progranulin can be endocytosed through the sortilin receptor and delivered to lysosomes. In neurons, PGRN i) enhances survival and neurite outgrowth through modulation of GSK-3β, ii) colocalizes in late endosomes and early lysosomes with the transmembrane protein TMEM106B, iii) co-localizes with markers such as BDNF along axons and iv) influences synaptic structure and function at synaptic and extra-synaptic sites, where it is secreted in an activity-dependent manner. Therefore, ongoing research has implicated PGRN in multiple neurodegenerative diseases in addition to its prominent role as a cause of FTLD.

Selected Reviews: Progranulin: at the interface of neurodegenerative and metabolic diseases: A.D. Nguyen, et al.; Trends Endocrinol. Metab. 24, 597 (2013) • Progranulin in neurodegenerative disease: T.L. Petkau & B.R. Leavitt; TINS 37, 388 (2014)

Tag-free Progranulins — Unique Tools for in vivo research

  • Higher activity compared to tagged Progranulins
  • Suitable for in vitro and in vivo studies
  • Reflects the native sequence with no additional amino acids
  • Correct processed protein (at the N-terminus)
  • Affinity purified
  • Low endotoxin levels (<0.1eu/μg)

Progranulin - Bulk Available

Recombinant Human, Mouse or Rat Progranulin

Cat. No.
DescriptionAmountBrand
AG-40A-0188Y
Progranulin (human) (rec.) (untagged)
10 or 50 ug
AdipoGen
AG-40A-0189Y
Progranulin (mouse) (rec.) (untagged)
10 or 50 ug
AdipoGen
AG-40A-0196Y
Progranulin (rat) (rec.) (untagged)
10 or 50 ug
AdipoGen
AG-40A-0068Y
Progranulin (human) (rec.)
10 or 50 ug
AdipoGen
AG-40A-0194
Progranulin (rat) (rec.)10 or 50 ug
AdipoGen

Progranulin ELISA Kits


Cat. No.
DescriptionAmountBrand
AG-45A-0018Y
Progranulin (human) ELISA Kit
96 wells
AdipoGen
AG-45A-0019Y
Progranulin (mouse) ELISA Kit
96 wells
AdipoGen
AG-45A-0043Y
Progranulin (rat) ELISA Kit
96 wells
AdipoGen



Source:
Brochure: Neuroscience Research

Related to:
Brands: AdipoGen Life Sciences
Product groups: Assays, Proteins / Signaling Molecules