5 November 2012

Toll-like receptors

Toll-like receptors antibodies from GeneTex


The TLR family is the best characterized of the PRRs. They recognize a variety of PAMPs from bacteria (LPS, flagellin, CpG DNA), viruses (ssRNA, dsRNA) and fungi. There are three common pathways involved in TLR signaling: the MyD88-dependent, the alternative MyD88 and the TRIF-dependent pathways. Upon activation by PAMPs, all TLRs except TLR3 activate MyD88-dependent pathways to distinctly activate NF-KB, c-Jun and the subsequent inflammatory responses. Upon activation by viral RNA, TLR7/8 and TLR9 initiate an alternate MyD88 pathway to induce interferon expression and an antiviral response. The TRIF-dependent pathway is restricted to TLR3 and TLR4-TRAM signaling which mediates T cell stimulation.

TLR1CD14IRF5p65
TLR2c-JunIRF7PI3K
TLR3ERK1JNKRac1
TLR4ERK2LPSRIP1
TLR5FADDMD2TAB1
TLR6IKBMKK3TAB2
TLR7IKKMKK6TAK1
TLR8IKK-alphaMKKsTANK
TLR9IKK-betaMyD88TBK1
TLR10IRAK1NAP1TIRAP
TLR11IRAK2NFkBTRAF3
AktIRAK4OPNTRAF6
AP1IRAKMp38TRAM
Casp-8IRF3p50TRIF

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